2026年02月03日 星期二

> CTLA4基因敲除小鼠

品系名称Strain name CTLA4基因敲除小鼠
编号Number
品系编号Strain number
物种 小鼠
英文名English name CTLA4 Ko mice
别名Alias name CTLA4敲除小鼠
类别Category
基因信息Gene information
描述Description
传代Generation
外观特征Appearance features
遗传特征Genetic characteristics
培育历程Cultivation
相关亚系Related substrain
图片Picture
生物学特征Biological characteristics
寿命与疾病Life-span and disease 自身免疫疾病
应用领域Application area 免疫疾病研究
饲养与繁殖Breeding and reproduction 近交系方式
保种单位Preserving unit 产业处,中国医学科学院医学实验动物研究所,10021,北京市朝阳区潘家园南里5号,Tel:010-67776838,Fax:010-67770683,E-mail:chanyechu@cnilas.org
数据来源Data sources
录入/更新时间Date 2021.9.15
备注Remarks [1] Waterhouse P, Penninger JM, Timms E, et al. Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4[J]. Science, 1995, 270(5238): 985-8. [2] Tivol EA, Borriello F, Schweitzer AN, et al. Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4[J]. Immunity, 1995, 3(5): 541-7. [3] Sharpe AH, Freeman GJ. The B7-CD28 superfamily[J]. Nature reviews Immunology, 2002, 2(2): 116-26. [4] Egen JG, Kuhns MS, Allison JP. CTLA-4: new insights into its biological function and use in tumor immunotherapy[J]. Nature immunology, 2002, 3(7): 611-8. [5] Chambers CA, Sullivan TJ, Allison JP. Lymphoproliferation in CTLA-4-deficient mice is mediated by costimulation-dependent activation of CD4+ T cells[J]. Immunity, 1997, 7(6): 885-95.
品系可用性Strain Availability
特定条款和条件Specific Term and Conditions
保存状态Strain State Legend
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