2026年10月13日 星期二

> CTLA4基因敲除小鼠

品系名称Strain name CTLA4基因敲除小鼠
编号Number
品系编号Strain number
物种 小鼠
英文名English name CTLA4 Ko mice
别名Alias name CTLA4敲除小鼠
类别Category
基因信息Gene information
描述Description
传代Generation
外观特征Appearance features
遗传特征Genetic characteristics
培育历程Cultivation
相关亚系Related substrain 无
图片Picture
生物学特征Biological characteristics
寿命与疾病Life-span and disease 自身免疫疾病
应用领域Application area 免疫疾病研究
饲养与繁殖Breeding and reproduction 近交系方式
保种单位Preserving unit 产业处,中国医学科学院医学实验动物研究所,10021,北京市朝阳区潘家园南里5号,Tel:010-67776838,Fax:010-67770683,E-mail:chanyechu@cnilas.org
数据来源Data sources
录入/更新时间Date 2021.9.15
备注Remarks [1] Waterhouse P, Penninger JM, Timms E, et al. Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4[J]. Science, 1995, 270(5238): 985-8. [2] Tivol EA, Borriello F, Schweitzer AN, et al. Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4[J]. Immunity, 1995, 3(5): 541-7. [3] Sharpe AH, Freeman GJ. The B7-CD28 superfamily[J]. Nature reviews Immunology, 2002, 2(2): 116-26. [4] Egen JG, Kuhns MS, Allison JP. CTLA-4: new insights into its biological function and use in tumor immunotherapy[J]. Nature immunology, 2002, 3(7): 611-8. [5] Chambers CA, Sullivan TJ, Allison JP. Lymphoproliferation in CTLA-4-deficient mice is mediated by costimulation-dependent activation of CD4+ T cells[J]. Immunity, 1997, 7(6): 885-95.
品系可用性Strain Availability
特定条款和条件Specific Term and Conditions
保存状态Strain State Legend
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