2026年02月03日 星期二

> CTLA4人源化小鼠

品系名称Strain name CTLA4人源化小鼠
编号Number
品系编号Strain number
物种 小鼠
英文名English name CTLA4 humanized mice
别名Alias name CTLA4人源化小鼠
类别Category
基因信息Gene information
描述Description
传代Generation
外观特征Appearance features
遗传特征Genetic characteristics
培育历程Cultivation
相关亚系Related substrain
图片Picture
生物学特征Biological characteristics
寿命与疾病Life-span and disease 肿瘤抗体治疗
应用领域Application area 肿瘤抗体治疗研究
饲养与繁殖Breeding and reproduction 近交系方式
保种单位Preserving unit 产业处,中国医学科学院医学实验动物研究所,10021,北京市朝阳区潘家园南里5号,Tel:010-67776838,Fax:010-67770683,E-mail:chanyechu@cnilas.org
数据来源Data sources
录入/更新时间Date 2021.9.15
备注Remarks  [1] Rowshanravan B, Halliday N, Sansom DM. CTLA-4: a moving target in immunotherapy[J]. Blood, 2018, 131(1): 58-67.  [2] Park J, Kwon M, Shin EC. Immune checkpoint inhibitors for cancer treatment[J]. Archives of pharmacal research, 2016, 39(11): 1577-87.  [3] Lute KD, May KF, Jr., Lu P, et al. Human CTLA4 knock-in mice unravel the quantitative link between tumor immunity and autoimmunity induced by anti-CTLA-4 antibodies[J]. Blood, 2005, 106(9): 3127-33.  [4] Ipilimumab[J]. Drugs in R&D, 2010, 10(2): 97-110.  [5] Rotte A. Combination of CTLA-4 and PD-1 blockers for treatment of cancer[J]. Journal of experimental & clinical cancer research : CR, 2019, 38(1): 255.  [6] Tremelimumab[J]. Drugs in R&D, 2010, 10(2): 123-32.  [7] Antonia S, Goldberg SB, Balmanoukian A, et al. Safety and antitumour activity of durvalumab plus tremelimumab in non-small cell lung cancer: a multicentre, phase 1b study[J]. The Lancet Oncology, 2016, 17(3): 299-308.  [8] Bahig H, Aubin F, Stagg J, et al. Phase I/II trial of Durvalumab plus Tremelimumab and stereotactic body radiotherapy for metastatic head and neck carcinoma[J]. BMC cancer, 2019, 19(1): 68.  [9] Fumet JD, Isambert N, Hervieu A, et al. Phase Ib/II trial evaluating the safety, tolerability and immunological activity of durvalumab (MEDI4736) (anti-PD-L1) plus tremelimumab (anti-CTLA-4) combined with FOLFOX in patients with metastatic colorectal cancer[J]. ESMO open, 2018, 3(4): e000375.  [10] Lee JY, Kim JW, Lim MC, et al. A phase II study of neoadjuvant chemotherapy plus durvalumab and tremelimumab in advanced-stage ovarian cancer: a Korean Gynecologic Oncology Group Study (KGOG 3046), TRU-D[J]. Journal of gynecologic oncology, 2019, 30(6): e112.  [11] He M, Chai Y, Qi J, et al. Remarkably similar CTLA-4 binding properties of therapeutic ipilimumab and tremelimumab antibodies[J]. Oncotarget, 2017, 8(40): 67129-39.
品系可用性Strain Availability
特定条款和条件Specific Term and Conditions
保存状态Strain State Legend
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