| 中文名称Chinese name
|
SARS-CoV-MA15-ΔE滴鼻感染BALB/c 小鼠模型 |
| 编号Model number |
|
| 英文名称English name |
SARS-CoV-MA15-ΔE intranasally infection BALB/c mouse model |
| 物种Species name |
小鼠
|
| 品系Strain name |
|
| 人类疾病Human diseases |
SARS |
| 传染性Infectivity |
是 |
| 微生物Microorganism |
|
| 类别Category |
SARS-CoV感染动物模型 |
| 造模因素Modeling factors |
|
| 制作方法Making method |
We infected BALB/c mice with either the mouse-adapted virulent SARS-CoV-MA15-WT (Roberts et al., 2007)—which recapitulates infection in humans, including severe lung disease and mortality—or the
attenuated SARS-CoV-MA15-ΔE, causing mild lung inflammation (DeDiego et al., 2007). |
| 生物学特征Biological characteristics |
|
| 医学用途Medical use |
用于SARS-CoV致病机制研究、疫苗和药物评估。 |
| 临床表现Clinical manifestation |
|
| 病理表现Pathology |
|
| 发病天数Days of onset |
|
| 发病过程Pathogenesis process |
|
| 临床诊断Clinical diagnosis |
病毒在肺中复制 |
| 评价模型成功的指标Indicators for evaluating model success |
|
| 保藏单位Preservation unit |
马德里国家生物技术中心@@http://www.cnb.csic.es/index.php/en/ |
| 参考文献Reference |
SARS-CoV-Encoded Small RNAs Contribute to Infection-Associated Lung Pathology.,PMID:28216251,DOI:10.1016/j.chom.2017.01.015 |
| 录入/更新时间Date |
2021.7.20 |
| 备注Remarks |
|
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