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> AIDs SIV/DeltaB670血液感染猪尾猕猴模型
| 中文名称Chinese name | AIDs SIV/DeltaB670血液感染猪尾猕猴模型 |
|---|---|
| 编号Model number | |
| 英文名称English name | AIDs SIV/DeltaB670 intravenously infected pig-tailed Macaque model |
| 物种Species name | 猴 |
| 品系Strain name | |
| 人类疾病Human diseases | HIV |
| 传染性Infectivity | 是 |
| 微生物Microorganism | |
| 类别Category | HIV感染动物模型 |
| 造模因素Modeling factors | |
| 制作方法Making method | Macaques were treated at 12 days postinoculation (dpi) with 30 mg/kg of body weight of tenofovir (Gilead, Foster City, CA) for the first 2 weeks and then with 10 mg/kg of tenofovir once daily intramuscularly as previously described , as well as with 480 mg/kg darunavir (Janssen, Titusville, NJ), 10 mg/kg of integrase inhibitor L000870812 (Merck, Kenilworth, NJ), and 24 mg/kg ritonavir (AbbVie, North Chicago, IL); the last three drugs were administered orally twice daily. In addition to antiretroviral drugs. |
| 生物学特征Biological characteristics | |
| 医学用途Medical use | 用于HIV致病机制研究、疫苗和药物评估。 |
| 临床表现Clinical manifestation | |
| 病理表现Pathology | |
| 发病天数Days of onset | |
| 发病过程Pathogenesis process | |
| 临床诊断Clinical diagnosis | |
| 评价模型成功的指标Indicators for evaluating model success | |
| 保藏单位Preservation unit | 约翰霍普金斯医学院@@https://www.hopkinsmedicine.org/som/ |
| 参考文献Reference | Infectious Virus Persists in CD4+ T Cells and Macrophages in Antiretroviral Therapy-Suppressed Simian Immunodeficiency Virus-Infected Macaques.,PMID:31118264,DOI:10.1038/nmicrobiol.2016.276 |
| 录入/更新时间Date | 2021.7.20 |
| 备注Remarks |
