| 中文名称Chinese name
|
MERS-CoV hCoV-EMC/2012 口鼻眼气管联合感染绒猴模型 |
| 编号Model number |
|
| 英文名称English name |
MERS-CoV hCoV-EMC/2012 oral nasal tracheal and eye infected common marmosets model |
| 物种Species name |
猴
|
| 品系Strain name |
|
| 人类疾病Human diseases |
MERS |
| 传染性Infectivity |
是 |
| 微生物Microorganism |
|
| 类别Category |
MERS-CoV感染动物模型 |
| 造模因素Modeling factors |
|
| 制作方法Making method |
Animals were intravenously infused with 30 mg/kg of mAb LCA60. Animals were inoculated with MERS-CoV (strain hCoV-EMC/2012) by a combination of four routes with a total dose of dose 5.2 × 10^6 TCID50 (intranasally with 100 μl in each nare, orally with 500 μl, intratracheally with 500 μl and in each eye with 50 μl of DMEM containing 4 × 10^6 TCID50/ml) |
| 生物学特征Biological characteristics |
|
| 医学用途Medical use |
用于MERS致病机制研究、疫苗和药物评估。 |
| 临床表现Clinical manifestation |
|
| 病理表现Pathology |
|
| 发病天数Days of onset |
|
| 发病过程Pathogenesis process |
|
| 临床诊断Clinical diagnosis |
|
| 评价模型成功的指标Indicators for evaluating model success |
|
| 保藏单位Preservation unit |
美国国立卫生研究院@@https://www.nih.gov/about-nih/what-we-do/nih-almanac/national-institute-allergy-infectious-diseases-niaid |
| 参考文献Reference |
Prophylactic efficacy of a human monoclonal antibody against MERS-CoV in the common marmoset.,PMID:30684561,DOI:10.1038/nmicrobiol.2016.283 |
| 录入/更新时间Date |
2021.7.20 |
| 备注Remarks |
|
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