| 中文名称Chinese name
|
MERS-CoV Qatar15/2015 接触感染免疫羊驼模型 |
| 编号Model number |
|
| 英文名称English name |
MERS-CoV Qatar15/2015 contact infected and immunized llamas model |
| 物种Species name |
羊驼
|
| 品系Strain name |
|
| 人类疾病Human diseases |
MERS |
| 传染性Infectivity |
是 |
| 微生物Microorganism |
|
| 类别Category |
MERS-CoV感染动物模型 |
| 造模因素Modeling factors |
|
| 制作方法Making method |
Llamas were prime vaccinated each with 35 μg of a recombinant S1 protein produced in a baculovirus system, emulsified (1:1 volume) with Montanide™ ISA 206 VG (Seppic) adjuvant and intramuscularly administered (2 ml per animal and dose) in the right side of the neck. A boosting immunization was conducted 3 weeks later as above (left side of the neck) but with 50 μg of recombinant S1 protein produced in HEK 293 T cells, emulsified (1:1 volume) with Montanide™ISA 206 VG (Seppic) adjuvant. At day 37, A12-A16 were brought in contact with A4-A6. |
| 生物学特征Biological characteristics |
|
| 医学用途Medical use |
用于MERS致病机制研究、疫苗和药物评估。 |
| 临床表现Clinical manifestation |
|
| 病理表现Pathology |
|
| 发病天数Days of onset |
|
| 发病过程Pathogenesis process |
|
| 临床诊断Clinical diagnosis |
|
| 评价模型成功的指标Indicators for evaluating model success |
|
| 保藏单位Preservation unit |
IRTA CReSA动物健康研究中心@@http://www.cresa.cat/cresa3/default.asp?mod=strmenu01&idioma=en |
| 参考文献Reference |
Blocking transmission of Middle East respiratory syndrome coronavirus (MERS-CoV) in llamas by vaccination with a recombinant spike protein.,PMID:31711379,DOI:10.1038/nmicrobiol.2016.293 |
| 录入/更新时间Date |
2021.7.20 |
| 备注Remarks |
|
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