| 中文名称Chinese name
|
SARS-CoV Tor2滴鼻感染雪貂模型 |
| 编号Model number |
|
| 英文名称English name |
SARS-CoV Tor2 intranasally infection ferret model |
| 物种Species name |
雪貂
|
| 品系Strain name |
雪貂
|
| 人类疾病Human diseases |
SARS |
| 传染性Infectivity |
是 |
| 微生物Microorganism |
|
| 类别Category |
SARS-CoV感染动物模型 |
| 造模因素Modeling factors |
|
| 制作方法Making method |
Ferrets (groups of eight) were anaesthetized with ketamine (25 mg kg21), xylazine (2 mg kg21) and atropine (0.05 mg kg21). 26109 p.f.u. of the Ad5 virus stock (Ad-Ctrl) i.n.Ferrets were anaesthetized as above and challenged with 106 p.f.u. SARS-CoV Tor2 in 0.5 ml PBS i.n. at 7 weeks from the initial immunization. |
| 生物学特征Biological characteristics |
|
| 医学用途Medical use |
用于SARS-CoV致病机制研究、疫苗和药物评估。 |
| 临床表现Clinical manifestation |
|
| 病理表现Pathology |
|
| 发病天数Days of onset |
|
| 发病过程Pathogenesis process |
|
| 临床诊断Clinical diagnosis |
病毒在肺中复制 |
| 评价模型成功的指标Indicators for evaluating model success |
|
| 保藏单位Preservation unit |
不列颠哥伦比亚大学疾病控制中心@@http://covid-19.bccdc.ca/ |
| 参考文献Reference |
Severe acute respiratory syndrome vaccine efficacy in ferrets: whole killed virus and adenovirus-vectored vaccines.,PMID:18753223,DOI:10.1099/vir.0.2008/001891-0 |
| 录入/更新时间Date |
2021.7.20 |
| 备注Remarks |
|
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