| 中文名称Chinese name
|
MERS-CoV EMC/2012滴鼻感染新西兰白兔模型 |
| 编号Model number |
|
| 英文名称English name |
MERS-CoV EMC/2012 intransally infection of New Zealand white rabbit model |
| 物种Species name |
兔
|
| 品系Strain name |
|
| 人类疾病Human diseases |
MERS |
| 传染性Infectivity |
是 |
| 微生物Microorganism |
|
| 类别Category |
MERS-CoV感染动物模型 |
| 造模因素Modeling factors |
|
| 制作方法Making method |
Male New Zealand white rabbits (Covance, Princeton, NJ) between five to nine months of age were anesthetized with a combination of intramuscular dexmedetomidine and isoflurane inhalation. Animals were inoculated intranasally (i.n.) with virus diluted in 1ml of MERS-CoV in Leibovitz-15 (L15) media (GIBCO), or mock-infected with 1ml of media alone. Rabbits following infection with either 103 or 105 TCID50 of EMC/2012 strain. n = 3 rabbits per group. |
| 生物学特征Biological characteristics |
|
| 医学用途Medical use |
用于MERS致病机制研究、疫苗和药物评估。 |
| 临床表现Clinical manifestation |
|
| 病理表现Pathology |
|
| 发病天数Days of onset |
|
| 发病过程Pathogenesis process |
|
| 临床诊断Clinical diagnosis |
|
| 评价模型成功的指标Indicators for evaluating model success |
|
| 保藏单位Preservation unit |
美国国家过敏和传染病研究所@@https://www.niaid.nih.gov/ |
| 参考文献Reference |
Enhanced inflammation in New Zealand white rabbits when MERS-CoV reinfection occurs in the absence of neutralizing antibody.,PMID:28817732,DOI:10.1038/nmicrobiol.2016.290 |
| 录入/更新时间Date |
2021.7.20 |
| 备注Remarks |
|
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