MERS-CoV 3B11预处理滴鼻感染 MERS-15 C2 288-330+/+小鼠模型

中文名称Chinese name	MERS-CoV 3B11预处理滴鼻感染 MERS-15 C2 288-330+/+小鼠模型
编号Model number
英文名称English name	MERS-CoV 3B11 pre-infection treated MERS-15 intansally infection 288-330+/+ mouse model
物种Species name	小鼠
品系Strain name
人类疾病Human diseases	MERS
传染性Infectivity	是
微生物Microorganism
类别Category	MERS-CoV感染动物模型
造模因素Modeling factors
制作方法Making method	Human monoclonal antibody, 3B11, protects mice from severe respiratory disease. 288-330+/+ mice were intraperitoneally administered 250ug of 3B11 or isotype control antibody 12 hours prior to challenge with 5×106 PFU of MERS-15 C2. Mortality (a) and mouse weights (b) were monitored daily for mice receiving 3B11 human monoclonal antibody (n = 12) or isotype control antibody (n = 12) through day 6 p.i.
生物学特征Biological characteristics
医学用途Medical use	用于MERS致病机制研究、疫苗和药物评估。
临床表现Clinical manifestation
病理表现Pathology
发病天数Days of onset
发病过程Pathogenesis process
临床诊断Clinical diagnosis
评价模型成功的指标Indicators for evaluating model success
保藏单位Preservation unit	北卡罗来纳大学教堂山分校@@https://www.unc.edu/
参考文献Reference	A mouse model for MERS coronavirus-induced acute respiratory distress syndrome.,PMID:27892925,DOI:10.1038/nmicrobiol.2016.232
录入/更新时间Date	2021.7.20
备注Remarks