| 中文名称Chinese name
|
SARS-CoV PRCV-ISU-1滴鼻气管途径联合感染小猪模型 |
| 编号Model number |
|
| 英文名称English name |
SARS-CoV PRCV-ISU-1 intranasally and intratracheally infection piglet model |
| 物种Species name |
猪
|
| 品系Strain name |
|
| 人类疾病Human diseases |
SARS |
| 传染性Infectivity |
是 |
| 微生物Microorganism |
|
| 类别Category |
SARS-CoV感染动物模型 |
| 造模因素Modeling factors |
|
| 制作方法Making method |
The two PRCV pig groups were inoculated with PRCV via the intranasal (i.n.) and intratracheal (i.t.) routes using a total of 1×10^7 PFU of PRCV in 5 ml medium per pig, with 3 ml i.t. and 1 ml i.n. in each nostril. The i.t. inoculation was performed by sedating the pigs followed by an intubation procedure as an alternate to reported procedures. The anti-inflammatory corticosteroid DEX (VEDCO, St. Joseph, MO), was given daily by intramuscular injection at 2 mg/kg body weight (PRCV/DEX and Mock/DEX groups) from postinoculation days 1 to 6 (PID 1 to 6). |
| 生物学特征Biological characteristics |
|
| 医学用途Medical use |
用于SARS-CoV致病机制研究、疫苗和药物评估。 |
| 临床表现Clinical manifestation |
|
| 病理表现Pathology |
|
| 发病天数Days of onset |
|
| 发病过程Pathogenesis process |
|
| 临床诊断Clinical diagnosis |
|
| 评价模型成功的指标Indicators for evaluating model success |
|
| 保藏单位Preservation unit |
俄亥俄州立大学@@https://www.osu.edu/ |
| 参考文献Reference |
Cytokine responses in porcine respiratory coronavirus-infected pigs treated with corticosteroids as a model for severe acute respiratory syndrome.,PMID:18287230,DOI:10.1128/JVI.02190-07 |
| 录入/更新时间Date |
2021.7.20 |
| 备注Remarks |
|
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