| 中文名称Chinese name
|
SARS-CoV BJ01滴鼻感染金色叙利亚仓鼠模型 |
| 编号Model number |
|
| 英文名称English name |
SARS-CoV BJ01 intransally infection golden Syrian hamsters model |
| 物种Species name |
仓鼠
|
| 品系Strain name |
|
| 人类疾病Human diseases |
SARS |
| 传染性Infectivity |
是 |
| 微生物Microorganism |
|
| 类别Category |
SARS-CoV感染动物模型 |
| 造模因素Modeling factors |
|
| 制作方法Making method |
For therapeutic effect assays, 1×10^4 TCID50 of SARS-CoV in 100μL of phosphate-buffered saline (PBS) buffer was inoculated intranasally into each hamster on day 0. The indicated amount of nonimmune equine F(ab')2 control or equine anti-SARS-CoV F(ab')2 was injected intraperitoneally on day 1 postinfection (day 0), and viral titers were examined on the following 4 d (days 2–5;), or on days 3–5 postinfection, respectively. |
| 生物学特征Biological characteristics |
|
| 医学用途Medical use |
用于SARS-CoV致病机制研究、疫苗和药物评估。 |
| 临床表现Clinical manifestation |
|
| 病理表现Pathology |
|
| 发病天数Days of onset |
|
| 发病过程Pathogenesis process |
|
| 临床诊断Clinical diagnosis |
|
| 评价模型成功的指标Indicators for evaluating model success |
|
| 保藏单位Preservation unit |
军事医学科学院 微生物流行病研究所@@https://www.natureindex.com/institution-outputs/china/beijing-institute-of-microbiology-and-epidemiology-amms/513906ba34d6b65e6a000060 |
| 参考文献Reference |
Inhibition of severe acute respiratory syndrome-associated coronavirus infection by equine neutralizing antibody in golden Syrian hamsters.,PMID:17425434,DOI:10.1089/vim.2006.0064 |
| 录入/更新时间Date |
2021.7.20 |
| 备注Remarks |
|
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