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> MERS-CoV Jordan 鼻内感染 BALB/c小鼠模型
| 中文名称Chinese name | MERS-CoV Jordan 鼻内感染 BALB/c小鼠模型 |
|---|---|
| 编号Model number | |
| 英文名称English name | MERS-CoV Jordan intranasally infected BALB/c mice model |
| 物种Species name | 小鼠 |
| 品系Strain name | |
| 人类疾病Human diseases | MERS |
| 传染性Infectivity | 是 |
| 微生物Microorganism | |
| 类别Category | MERS-CoV感染动物模型 |
| 造模因素Modeling factors | |
| 制作方法Making method | Ten mice were inoculated intramuscularly with 10 ug of chemically inactivated BNSP333-S1-G particles in 100 ul PBS and boosted twice with the same amount of virus on day 7 and day 21, respectively. Groups of five mice were immunized with BNSP333-GP, BNSP333, or PBS as controls according to the same immunization schedule.Mice were inoculated with 2.5 x 10^3PFU of MERS-CoV (Jordan) in a 50-ul total volume. |
| 生物学特征Biological characteristics | |
| 医学用途Medical use | 用于MERS致病机制研究、疫苗和药物评估。 |
| 临床表现Clinical manifestation | |
| 病理表现Pathology | |
| 发病天数Days of onset | |
| 发病过程Pathogenesis process | |
| 临床诊断Clinical diagnosis | |
| 评价模型成功的指标Indicators for evaluating model success | |
| 保藏单位Preservation unit | 托马斯杰斐逊大学Sidney Kimmel医学院@@https://www.jefferson.edu/academics/colleges-schools-institutes/skmc.html |
| 参考文献Reference | NA,NA,NA |
| 录入/更新时间Date | 2021.7.20 |
| 备注Remarks |
