| 中文名称Chinese name
|
MERS-CoV MERS-15 clone 2滴鼻感染C57Bl/6J野生小鼠模型 |
| 编号Model number |
|
| 英文名称English name |
MERS-CoV MERS-15 clone 2 intranasally infection wild type C57Bl/6J mouse model |
| 物种Species name |
小鼠
|
| 品系Strain name |
|
| 人类疾病Human diseases |
MERS |
| 传染性Infectivity |
是 |
| 微生物Microorganism |
|
| 类别Category |
MERS-CoV感染动物模型 |
| 造模因素Modeling factors |
|
| 制作方法Making method |
Clonal isolates of mouse-adapted MERS-CoV exhibit severe respiratory disease. Mice were inoculated intranasally with 5×10 PFU. Mortality of 288-330+/+ + MERS-15 clone 1 (MERS-15 C1) (n = 7) or MERS-15 clone 2 (MERS-15 C2) (n = 11) was monitored daily through day 6 p.i. Data reflect percent of surviving mice. (b) Mouse weights were monitored daily for 288-330+/+ + MERS-15 C1 (n = 7); 288-330+/+ + MERS-15 C2 (n = 11); 288-330+/+ + MERS-0 (n = 6); and C57Bl/6J wt + MERS-15 C2 (n = 6). |
| 生物学特征Biological characteristics |
|
| 医学用途Medical use |
用于MERS致病机制研究、疫苗和药物评估。 |
| 临床表现Clinical manifestation |
|
| 病理表现Pathology |
|
| 发病天数Days of onset |
|
| 发病过程Pathogenesis process |
|
| 临床诊断Clinical diagnosis |
|
| 评价模型成功的指标Indicators for evaluating model success |
|
| 保藏单位Preservation unit |
北卡罗来纳大学教堂山分校@@https://www.unc.edu/ |
| 参考文献Reference |
A mouse model for MERS coronavirus-induced acute respiratory distress syndrome.,PMID:27892925,DOI:10.1038/nmicrobiol.2016.236 |
| 录入/更新时间Date |
2021.7.20 |
| 备注Remarks |
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