| 中文名称Chinese name
|
COVID-19 BetaCoV/Belgium/GHB-03021/2020滴鼻感染BALB/c SCID小鼠模型 |
| 编号Model number |
|
| 英文名称English name |
COVID-19 BetaCoV/Belgium/GHB-03021/2020 intranally infection BALB/c SCID mouse model |
| 物种Species name |
小鼠
|
| 品系Strain name |
|
| 人类疾病Human diseases |
COVID-19 |
| 传染性Infectivity |
是 |
| 微生物Microorganism |
|
| 类别Category |
新型冠状病毒动物模型 |
| 造模因素Modeling factors |
|
| 制作方法Making method |
Schematic representation of SARS-CoV-2 inoculation schedule. Several wild-type (WT) and knock-out mouse strains were intranasally inoculated with 2 * 10**5 TCID50 of passage 4 (P4) SARS-CoV-2. Convalescent serum treatment was given intraperitoneally (i.p.) 1 day prior to inoculation. |
| 生物学特征Biological characteristics |
|
| 医学用途Medical use |
用于新冠肺炎COVID-19致病机制研究、疫苗和药物评估。 |
| 临床表现Clinical manifestation |
|
| 病理表现Pathology |
|
| 发病天数Days of onset |
|
| 发病过程Pathogenesis process |
|
| 临床诊断Clinical diagnosis |
|
| 评价模型成功的指标Indicators for evaluating model success |
|
| 保藏单位Preservation unit |
比利时鲁汶大学@@https://www.kuleuven.be/wieiswie/en/unit/50000698 |
| 参考文献Reference |
STAT2 signaling as double-edged sword restricting viral dissemination but driving severe pneumonia in SARS-CoV-2 infected hamsters,NA,DOI:10.1101/2020.04.23.056838 |
| 录入/更新时间Date |
2021.7.20 |
| 备注Remarks |
|
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