| 中文名称Chinese name
|
SIV mac251直肠途径感染猕猴模型 |
| 编号Model number |
|
| 英文名称English name |
SIV mac251 intrarectally infected Rhesus macaques model |
| 物种Species name |
猴
|
| 品系Strain name |
|
| 人类疾病Human diseases |
HIV |
| 传染性Infectivity |
是 |
| 微生物Microorganism |
|
| 类别Category |
HIV感染动物模型 |
| 造模因素Modeling factors |
|
| 制作方法Making method |
Three vaccines were tested in groups of 8 MCM with each animal being vaccinated intradermally or intramuscularly with 100μg DNA primes at weeks 0, 4 and 8 and a rAd5 boost (6x1010 particles) at week 16.Eight unvaccinated animals served as controls for each group challenged with the same virus stock.The IM vaccination experiments were performed subsequent to the ID vaccinations and employed an additional group of 8 control animals that were challenged in parallel. From week 23 the animals were challenged intrarectally with 150TCID50 of SIVmac251 at weekly intervals for up to 10 weeks or until they became infected, as determined by virus in the plasma. |
| 生物学特征Biological characteristics |
|
| 医学用途Medical use |
用于HIV致病机制研究、疫苗和药物评估。 |
| 临床表现Clinical manifestation |
|
| 病理表现Pathology |
|
| 发病天数Days of onset |
|
| 发病过程Pathogenesis process |
|
| 临床诊断Clinical diagnosis |
病毒在血液中复制 |
| 评价模型成功的指标Indicators for evaluating model success |
|
| 保藏单位Preservation unit |
英国国立生物标准与控制研究所@@https://www.nibsc.org/ |
| 参考文献Reference |
Vaccination of macaques with DNA followed by adenoviral vectors encoding SIV gag alone delays infection by repeated mucosal challenge with SIV.,PMID:31413132,DOI:10.1128/JVI.00606-19 |
| 录入/更新时间Date |
2021.7.20 |
| 备注Remarks |
|
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