| 中文名称Chinese name
|
influenza A/Jiangxi-Donghu/346/13 (H10N8)滴鼻感染BALB/c小鼠模型 |
| 编号Model number |
|
| 英文名称English name |
influenza A/Jiangxi-Donghu/346/13 (H10N8) intransally infection mouse model |
| 物种Species name |
小鼠
|
| 品系Strain name |
BALB/c小鼠
|
| 人类疾病Human diseases |
influenza |
| 传染性Infectivity |
是 |
| 微生物Microorganism |
|
| 类别Category |
流感感染动物模型 |
| 造模因素Modeling factors |
|
| 制作方法Making method |
In prophylactic studies, groups of five female BALB/c mice (The Jackson Laboratory) aged 6 to 8 weeks received a 5-, 1-, or 0.5-mg/kg dose of purified mouse monoclonal antibody intraperitoneally (anti-H10 head MAb 1B10 [IgG2b], anti-stalk MAbs 9H10 [IgG2a], anti-N8 antibody 2E11 [IgG2b], and control MAb 8H9 [anti-H6]). At 2 h after treatment, the mice were anesthetized using a ketamine-xylazine mixture and infected with 5×the 50% lethal dose (LD50) of JD13 (H10N8) virus diluted in PBS. |
| 生物学特征Biological characteristics |
|
| 医学用途Medical use |
用于流感致病机制研究、疫苗和药物评估。 |
| 临床表现Clinical manifestation |
|
| 病理表现Pathology |
|
| 发病天数Days of onset |
|
| 发病过程Pathogenesis process |
|
| 临床诊断Clinical diagnosis |
体重下降 |
| 评价模型成功的指标Indicators for evaluating model success |
|
| 保藏单位Preservation unit |
西奈山伊坎医学院@@https://icahn.mssm.edu/ |
| 参考文献Reference |
Hemagglutinin Stalk- and Neuraminidase-Specific Monoclonal Antibodies Protect against Lethal H10N8 Influenza Virus Infection in Mice.,PMID:26512088,DOI:10.1038/nmicrobiol.2016.264 |
| 录入/更新时间Date |
2021.7.20 |
| 备注Remarks |
|
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