| 中文名称Chinese name
|
SARS-CoV icGD03滴鼻感染叙利亚仓鼠模型 |
| 编号Model number |
|
| 英文名称English name |
SARS-CoV icGD03 intranasally infection Syrian golden hamster model |
| 物种Species name |
仓鼠
|
| 品系Strain name |
叙利亚仓鼠
|
| 人类疾病Human diseases |
SARS |
| 传染性Infectivity |
是 |
| 微生物Microorganism |
|
| 类别Category |
SARS-CoV感染动物模型 |
| 造模因素Modeling factors |
|
| 制作方法Making method |
Primary replication and replication after challenge of SARS-CoV in hamster lungs. Golden Syrian hamsters (50–55 days old) were intranasally inoculated with one of four SARS-CoV strains (A) HK-39 (N= 16), (B) Urbani (N= 16), (C) Frk-1 (N= 16), and (D) icGD03 (N= 12) of SARS-CoV (103 TCID50/hamster). For evaluating viral replication following primary (1◦) infection, four hamsters per strain (three hamsters for icGD03) were sacrificed at day 2 post-infection. For evaluation of protection from secondary (2◦) infection, the remaining hamsters were challenged 28 days after 1◦ infection with the indicated homologous or heterologous strain of SARS-CoV (N= 4 per group; or N= 3/group for icGD03; 103 TCID50/hamster) and sacrificed 2 days later. |
| 生物学特征Biological characteristics |
|
| 医学用途Medical use |
用于SARS-CoV致病机制研究、疫苗和药物评估。 |
| 临床表现Clinical manifestation |
|
| 病理表现Pathology |
|
| 发病天数Days of onset |
|
| 发病过程Pathogenesis process |
|
| 临床诊断Clinical diagnosis |
|
| 评价模型成功的指标Indicators for evaluating model success |
|
| 保藏单位Preservation unit |
美国传染病实验室@@https://www.niaid.nih.gov/research/lab-infectious-diseases |
| 参考文献Reference |
Rhesus angiotensin converting enzyme 2 supports entry of severe acute respiratory syndrome coronavirus in Chinese macaques.,PMID:18801550,DOI:10.1016/j.virol.2008.08.016 |
| 录入/更新时间Date |
2021.7.20 |
| 备注Remarks |
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