| 中文名称Chinese name
|
MERS-CoV EMC/2012气管途径感染狨猴模型 |
| 编号Model number |
|
| 英文名称English name |
MERS-CoV EMC/2012 intracheally infection marmoset model |
| 物种Species name |
猴
|
| 品系Strain name |
狨猴
|
| 人类疾病Human diseases |
MERS |
| 传染性Infectivity |
是 |
| 微生物Microorganism |
|
| 类别Category |
MERS-CoV感染动物模型 |
| 造模因素Modeling factors |
|
| 制作方法Making method |
Common marmosets inoculated with 5×106 TCID50 of MERS-CoV in 500 µl of DMEM intra-tracheally.The animals were randomly assigned to one of four treatment groups in a non-blinded manner Each
treatment group included three animals. We administered MMF intraperitoneally and interferon-β1b subcutaneously instead of intravenously or orally respectively.We initiated treatment with MMF and
interferon-β1b at 8 hours post-inoculation (hpi). |
| 生物学特征Biological characteristics |
|
| 医学用途Medical use |
用于MERS致病机制研究、疫苗和药物评估。 |
| 临床表现Clinical manifestation |
|
| 病理表现Pathology |
|
| 发病天数Days of onset |
|
| 发病过程Pathogenesis process |
|
| 临床诊断Clinical diagnosis |
体重下降 |
| 评价模型成功的指标Indicators for evaluating model success |
|
| 保藏单位Preservation unit |
香港大学@@https://www.natureindex.com/institution-outputs/china/state-key-laboratory-of-emerging-infectious-diseases-hku/553f485f140ba0de088b4571 |
| 参考文献Reference |
Treatment With Lopinavir/Ritonavir or Interferon-β1b Improves Outcome of MERS-CoV Infection in a Nonhuman Primate Model of Common Marmoset.,PMID:26198719,DOI:10.1093/infdis/jiv392 |
| 录入/更新时间Date |
2021.7.20 |
| 备注Remarks |
|
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